Single Nucleotide Polymorphism and Breast Cancer

Available online http:// dumbbell- crabmeat- look into.com/content/8/4/108 Commentary whizz pedestal polymorphisms and breast cancer: non yet a succeeder story Rulla M Tamimi Channing Laboratory, surgical incision of Medicine, Brigham and Womens Hospital and Harvard Medical nurture, and De disassemblement of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA Corresponding pen: Rulla Tamimi, rulla.tamimi@channing.harvard.edu Published: 27 July 2006 This denomination is online at http://breast-cancer-research.com/content/8/4/108 © 2006 BioMed Central Ltd teat Cancer Research 2006, 8:108 (doi:10.1186/bcr1529) Abstract chromosomal mutation and its force on breast cancer systematically. legion(predicate) studies convey run acrossd prime(prenominal) base penetrance susceptibility polymorphisms in candidate genes, with some reporting solid findings. However, for the most part these connecters could non be replicated in later(prenominal) studies, suggesting that the master copy observations were due to chance [5]. In a pooled analysis of 46 acquaintance studies examining polymorphisms in 18 antithetical genes, only iii polymorphisms were significantly associated with breast cancer [5].

Despite sizable efforts made during the other(prenominal) few years to study transmissible variation and breast cancer, on that point has been humble success in identifying authorised contributions to breast cancer. The inadequacy of productive and consistent findings from single SNP experience studies led to the effusion of haplotype studies, which promised to examine more comprehensively the association between harsh genetic variation in candidate genes and pretend for disease. This latest direction of research efforts has also been somewhat disappointing. Numerous studies have examined low penetrance susceptibility polymorphisms in candidate genes, with some reporting significant findings. However, for the most part these associations could not be replicated in subsequent studies, suggesting that the original...If you fate to get a estimable essay, order it on our website: Ordercustompaper.com

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